Muscle weakness in heart failure
Target validation,
Drug discovery / Therapeutics
Heart failure is thought to affect around 1 million people in the UK. Many patients with heart failure have severe muscle weakness but no effective drug treatments are available.
This team have previously discovered that a high level of a protein called MuRF1 may have an important role in this muscle weakness.
This project will further investigate the involvement in MuRF1 in heart failure-induced muscle weakness and aims to identify new drug treatments for loss of muscle strength. If effective, this will improve symptoms, quality of life and survival in heart failure patients.
The development of a new AI-supported model for imaging the heart based on data from over 700 people with atrial fibrillation, allow ablation to be more personalised to individual patients.
Cardiac patches for heart repair
A trial for every patient
Personalised angina care
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