Overwriting blood vessel identity to prevent graft failure

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Coronary heart disease (CHD) involves the narrowing of blood vessels around the heart.

If these vessels become blocked it can lead to a heart attack. One of the current treatments for heart disease is bypass surgery (CABG) where a grafted blood vessel taken from somewhere else in the body is used to bypass the blocked artery and restore blood flow to the heart.

However, the grafted blood vessel itself often becomes blocked, known as vein graft failure. This project will investigate new ways of preventing vein graft failure and improving the success of CABG surgery for treating patients with CHD.