Medical Research Project

Feasibility study for Randomised Controlled Trial of CUstodiol-HTK vs St Thomas’ solution for cardioplegia and cold static Storage of UK donor hearts in cardiac transplantation

Comparing fluids for preservation of donor hearts

In progress
07/11/2022
Transplant
East of England

Surgery, 

Clinical trial

Awarded amount: £199,294
Grant scheme: TRP
Institution: Royal Papworth Hospital NHS Foundation Trust
Principle Investigator: Dr Marius Berman

For a heart transplant to occur, a donor heart has to be acquired. When a donor heart is retrieved, it is flushed with a fluid in order to preserve it during transport.

Two different fluids are currently used; however, it is not known whether one is better than the other.

Better preservation of the heart may reduce ‘primary graft dysfunction’ (PGD) where the heart fails within the first 24 hours.

This project will explore the feasibility of a clinical trial by testing whether enough patients can be recruited in order to effectively investigate the difference between the two preservative fluids.

Apply for a Research Grant

Learn more

More Research Projects

3D heart modelling for personalised ablation

The development of a new AI-supported model for imaging the heart based on data from over 700 people with atrial fibrillation, allow ablation to be more personalised to individual patients.

In progress
19/06/2025
Read more

A National Clinical Trials Programme in UK Cardiac Surgery

A trial for every patient

In progress
13/03/2024
Read more
All Medical Research Projects

Donate to Research

Your gifts fund our life saving project

Give to Research