Medical Research Project

The effect of low-dose interleukin-2 on human atherosclerotic plaque immune cells at single cell resolution

Inflammation in narrowed blood vessels

In progress

04/11/2021

East of England

Drug discovery/ Therapeutics

Awarded amount: £191,476

Grant scheme: TRP

Institution: University of Cambridge

Principle Investigator: Prof Ziad Mallat


When blood vessels become narrowed, it can lead to heart attack and stroke.

This is caused by atherosclerosis which is due to a combination of build-up of fatty deposits within the blood vessel walls and the immune system reacting to these deposits, called inflammation. This project will test whether a protein called “interleukin-2” can reduce inflammation and atherosclerosis.

This could lead to the development of new treatments of the underlying process that causes heart attack and stroke.

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